Flinders Medical Centre Foundation
Flinders Medical Centre Foundation

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ANTIBODY TARGET FOR AUTOIMMUNE DISEASES

Thursday, 02 February 2012 12:01

A revolutionary medical breakthrough by researchers at Flinders University could pave the way to a cure for two debilitating autoimmune diseases.

PhD student Rhianna Lindop has developed a world-first technique in conjunction with Flinders proteomics experts Dr Georgia Arentz and Dr Tim Chataway to analyse a type of antibody that contributes to the disease progression of lupus and Sjogren's syndrome, resulting in vital new information that could ultimately lead to targeted therapies.

Lupus and Sjogren's syndrome are autoimmune diseases caused when the body mistakenly considers healthy tissue to be a harmful substance and, as a result, produces antibodies that actually attack the body's own organs.

"We all have proteins in our body but in people with autoimmune diseases the body recognises these 'self' proteins to be foreign and responds to them by producing antibodies that attack and destroy healthy tissues and organs," Ms Lindop (pictured with Flinders Professor Tom Gordon) said.

"Usually when you're sick the body produces antibodies to fight off the infection but it has the opposite effect in people with autoimmune diseases," she said.

Using a mass spectrometry machine, the researchers have - for the first time - analysed the antibody's molecular structure in 10 patients with lupus and Sjogren's to determine its sequence at a "protein level" rather than just on the genomic, or DNA scale, as previous research has done.

The findings have shown that all patients with the particular antibody demonstrated a common molecular signature.

"People always thought these antibodies were too complex to characterise but we found the antibody was restricted and common to all of the patients and specified by unique features," Ms Lindop said.

"This means that we can now focus on developing novel targeted therapies aimed at removing the antibody in people with lupus or Sjogren's - and the same research could also be applied to other antibodies associated with other autoimmune diseases."

With no cure for the two conditions, Ms Lindop said her groundbreaking research could lead to a "next generation of diagnostics and therapeutics".

"Current immunosuppressive treatments are aimed at reducing the effects of the disease but they don't actually alter the antibody so this research could allow us to develop a drug that specifically targets the antibody," she said.

"It's really exciting because it fits into the bench to bedside concept - we're doing research at the bench that actually translates to the hospital bed to improve lives."

Ms Lindop was a recent winner in Flinders University's Best Student Paper Award, a new initiative which aims to recognise, reward and promote excellence in student research.

Source: Flinders University

 

 

New Video Games Trialled for Cerebral Palsy

Thursday, 02 February 2012 11:39

Flinders University researchers are seeking children with cerebral palsy (CP) to take part in a ground-breaking new trial which may see hand function improved by playing special video games.

 

In South Australia, about 465 children are living with CP - an impairment of motor function or disability caused by a lesion or a mini-stoke in the brain in utero or in the first two years of their lives. Across Australia more than 34,000 children and adults are affected by the condition, which can have varying degrees of severity.

 

Lead researcher David Hobbs from the School of Computer Science, Engineering and Mathematics said their research is focussing on improving the sensory pathways, particularly to the hands, which are interrupted by CP.

 

"Many children with CP have a sensory deficit in their hands, which means they find it difficult to interact with the world around them such as gripping objects using the right pressure," David said.

 

"Because the brain can change and adapt, we hope to be able to change the way children with CP sense through their hands."


David's team have developed a number of specialised computer games suitable for children with CP which send vibrations through a specially developed controller.

"Most games and gaming controllers are too complex for children with CP to play and use," David said.  "Our games are custom made and the controller, developed in conjunction with UniSA, is less complex - which means children with CP can use it."

The team hope the children's brains will learn to take notice of the vibrations on the controller and therefore improve the overall sensitivity of the hands.

"Because the children are concentrating very hard on the game we hope their brains will be more responsive to the stimulus on their hands and will learn to recognise the vibrations."

The games have been trialled by 12-year old Emily Musitano, who has CP, to ensure they were interesting for children to play. Mum Rosemary Musitano said Emily "thoroughly enjoyed them".

The Flinders research team hope to now test the effect the games have on the sensory perception of children with CP in a large trial.

They are looking to recruit 100 suitable children to be assessed throughout 2012, with a view to conducting the in-home trial with the specialised computer games in 2013.


Parents of children with CP who are interested in participating in the trial can contact David directly on 8201 3167 or via email.

 

 

 

Smiling for Smiddy supports new Scholarship at FMC

Wednesday, 25 January 2012 10:57

A new PhD scholarship in a groundbreaking field of cancer prevention research has just been awarded to Flinders University student Cameron Dougherty thanks to funds raised by Queensland group Smiling for Smiddy.


Organisers chose the Flinders Medical Centre Foundation as a recipient of a $25,000 grant in 2009/10 to purchase a highly sensitive Rotor-Gene to help two different research groups find revolutionary new means of treating and preventing prostate cancer.


One of these groups is led by Professor Pam Sykes, whose world-leading research is examining whether low doses of radiation, such as those you might get from an x-ray or from air travel, can help prevent cancer by activating defences within normal cells which can help to kill cancer cells and protect against further radiation exposure.


The group believe low doses of radiation could be used to kill pretumour cells and prevent cancer forming and could be particularly effective against prostate cancer.


“We are also using the new Rotor-Gene to explore whether low doses of radiation can make chromosomes more stable and therefore less likely to become cancerous,” Professor Sykes said.


A new pledge from Smiling for Smiddy for $90,000 has funded a new PhD scholarship over three years which is allowing student Cameron Dougherty to continue and expand groundbreaking investigations into this exciting field of research.


“We hope to better determine the biological effects of these low doses of radiation, and the mechanism in which they induce protection from mutation and cancer,” Professor Sykes said.


“We are truly grateful for all the support which Smiling for Smiddy have provided for our work to date.”


Established in 2006 to commemorate the life of physiotherapist and keen cyclist Adam Smiddy, who passed away aged 26 to an aggressive cancer, the annual 1600km cycling event from Brisbane to Townsville has raised more than $1.9million for cancer services and research to date.


Fifty riders set off on the 5th annual Smiling for Smiddy ride on 3rd September 2011.

   

Claire's Coin the Cure 2011

Monday, 28 November 2011 09:14



Woodcroft teenager Claire Armstrong, 13, held a special fundraiser for the FMC Foundation at Westfield Marion on Sunday 23rd October and raised a wonderful $516 for breast cancer research.

Claire came up with the concept for Coin the Cure last year, and the idea has since been adopted by schools across the state. 

So far this remarkable young lady has raised more than $1,150 for breast cancer research through the FMC Foundation, and we are very blessed to have her support.

For more information on the schools Coin the Cure initiative click here.

 

New Motor Neuron Disease Study

Friday, 25 November 2011 15:06

Flinders researchers are embarking on a groundbreaking new study to test for a 'biomarker' in blood and urine samples of people with motor neuron disease (MND).

The research could one day lead to the use of new medications, and also aims to determine how advanced the disease is in people with MND. At present, the only way to establish stages of the condition is by visual assessment and some invasive techniques such as muscle biopsies.

MND is a fatal, non-curable disease which affects about 1,400 Australians at any one time. The disease impacts the motor neurons - the cells that control voluntary muscle activity including speaking, walking, breathing and swallowing.

In about 90 per cent of cases the patient has no family history of MND and the disease appears to have occurred without reason, while the remaining 10 per cent of cases are either hereditary or caused by an associated gene defect.

Led by Flinders University research fellow Dr Mary-Louise Rogers, the research team will analyse blood and urine samples for a specific molecule (called a biomarker) that may be present in people with MND.

The research, funded through a $16,000 grant from the FMC Foundation, will be used as 'proof of concept' in larger studies where the biomarker will be tested to see if it can measure the effectiveness of a range of clinical trial drugs in curing or delaying symptoms.

"Currently there is only one drug commercially available but it only improves quality of life for a few months," Dr Rogers said.

"We hope our research will be able to help pharmaceutical companies eliminate the drugs that are no good earlier in the process and continue investigating drugs that appear to be doing something."

While the project is still in its early stages, Dr Rogers said researchers would begin testing a small sample of people with MND in the coming months.

"Because it's such a horrible disease it's really important to find a cure, and if we have some way of knowing if drugs are working or not we can get those medications pushed through the clinical trial process a lot quicker."

   

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